Vanessa Helsing, a distant relative of the famous vampire hunter Abraham Van Helsing is resurrected, but soon realizes that the world was conquered by vampires. Tya is humanity's last hope to lead people to regain their lost.
In the days leading up to "The Rising," Vanessa is attacked and left for dead by an intruder. When Doc discovers anomalies in Vanessa's bloodwork, Axel and the marines come to retrieve the body, only to become marooned in the hospital when all hell breaks loose outside the building.
The hospital's power source is damaged, jeopardizing the protective UV lights. Vanessa and Axel head into Seattle to scavenge parts, leaving the others to fight against the vampires amongst themselves.
Vanessa and Mohamad head into the vampire-controlled streets in search of Vanessa's daughter; Cynthia is found dead at the hospital, and Doc thinks her apparent suicide is actually a deliberate murder; Vanessa is captured by vampires.
Vanessa, now in the clutches of Julius and his vampire brood, is forced to demonstrate her powers; the refugees discover a serial killer among the residents, and plot to wrestle control from Axel.
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